The Spike protein in the vaccines is toxic

Summarizing all the known science demonstrating that the Spike protein as used in the COVID-19 mRNA vaccines is toxic.

Like most vaccines, it was originally thought that the nanoparticles delivered by the mRNA vaccines would stay at the injection site. However, when this was tested in animal models it was found that the nanoparticles circulated throughout the body, concentrating in the adrenals, spleen, and ovaries to a small degree¹,² (p. 47). This is in line with previous research highlighting potential adverse effects of nanoparticles on the reproductive system³. Additionally, the CDC attest to the fact mRNA lasts just a few days in our bodies⁴. However, in January 2022 a study found that mRNA and the Spike protein that go along with it were detected in humans up to two months post-vaccination⁵.

The CDC currently describes the Spike protein produced by all of the COVID-19 vaccines as "harmless"⁶ to humans despite overwhelming evidence to the contrary. The pathogenicity of the Spike protein is far reaching, from endothelial and thrombotic disorder⁷,⁸,⁹,¹⁰,¹¹, to cellular damage and death¹²,¹³, to inhibition of DNA repair¹⁴, and finally to inflammation of the brain itself¹⁵.

The primary argument against this idea is that the Spike protein encoded by the vaccine is locked in it's S1 conformation, whereas the Spike in the wild virus is not. While true, the S1 protein alone has been shown to exhibit similar effects in the endothelium and brain¹⁶,¹⁷,¹⁸,¹⁹,²⁰,²¹,²². As it relates to effects seen post-vaccination, one study found increased endothelial inflammation²³ whereas another found spike antigen concentrations in the blood similar to that of acute infection²⁴. Interestingly, soluble Spike protein was found to be the cause of the severe thrombotic side effects in the vector-based COVID-19 vaccines²⁵.

Prior to the roll-out of the mass vaccination campaign, multiple studies indicated that more information was needed²⁶,²⁷ to be certain that the Spike protein used in vaccines we are injecting into the population are safe.

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1. Pharmacokinetics: Organ Distribution
https://files.catbox.moe/0vwcmj.pdf

2. EMA Assessment report (COVID-19 Vaccine Moderna)
https://www.ema.europa.eu/en/documents/assessment-report/spikevax-previously-covid-19-vaccine-moderna-epar-public-assessment-report_en.pdf

3. Potential adverse effects of nanoparticles on the reproductive system
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294055

4. Understanding mRNA COVID-19 Vaccines
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/mrna.html

5. Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination
https://www.cell.com/cell/fulltext/S0092-8674(22)00076-9

6. Understanding mRNA COVID-19 Vaccines
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/mrna.html

7. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.318902

8. SARS-CoV-2 Spike Protein Induces Degradation of Junctional Proteins That Maintain Endothelial Barrier Integrity
https://www.frontiersin.org/articles/10.3389/fcvm.2021.687783

9. The SARS-CoV-2 Spike protein alters human cardiac pericyte function and interaction with endothelial cells through a non-infective mechanism involving activation of CD147 receptor signalling
https://academic.oup.com/eurheartj/article/42/Supplement_1/ehab724.3383/6391566

10. SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009128

11. SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19
https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-00954-7

12. SARS-CoV-2 direct cardiac damage through spike-mediated cardiomyocyte fusion
https://europepmc.org/article/ppr/ppr232448

13. An evidence that SARS-Cov-2/COVID-19 spike protein (SP) damages hematopoietic stem/progenitor cells in the mechanism of pyroptosis in Nlrp3 inflammasome-dependent manner
https://www.nature.com/articles/s41375-021-01332-z

14. SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro
https://www.mdpi.com/1999-4915/13/10/2056

15. The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier
https://www.sciencedirect.com/science/article/pii/S096999612030406X

16. SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism
https://www.mdpi.com/1999-4915/13/11/2209

17. SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19
https://portlandpress.com/bioscirep/article/41/8/BSR20210611/229418/SARS-CoV-2-spike-protein-S1-induces-fibrin-ogen

18. The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells
https://journals.physiology.org/doi/full/10.1152/ajplung.00223.2021

19. Selectively expressing SARS-CoV-2 Spike protein S1 subunit in cardiomyocytes induces cardiac hypertrophy in mice
https://www.biorxiv.org/content/10.1101/2021.06.20.448993v1

20. The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice
https://www.nature.com/articles/s41593-020-00771-8

21. SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration
https://www.sciencedirect.com/science/article/pii/S0006291X2100499X

22. SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death
https://www.nature.com/articles/s41598-022-09410-7

23. Observational Findings of PULS Cardiac Test Findings for Inflammatory Markers in Patients Receiving mRNA Vaccines
https://www.ahajournals.org/doi/abs/10.1161/circ.144.suppl_1.10712

24. Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination
https://www.cell.com/cell/fulltext/S0092-8674(22)00076-9

25. “Vaccine-Induced Covid-19 Mimicry” Syndrome:Splice reactions within the SARS-CoV-2 Spike open reading frame result in Spike protein variants that may cause thromboembolic events in patients immunized with vector-based vaccines
https://www.researchsquare.com/article/rs-558954/v1

26. SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines
https://www.mdpi.com/2076-393X/9/1/36

27. Monitoring Serum Spike Protein with Disposable Photonic Biosensors Following SARS-CoV-2 Vaccination
https://www.mdpi.com/1424-8220/21/17/5857/htm